Lack of Evolutionary Conservation at Positions Important for Thermal Stability in the Yeast ODCase Protein
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چکیده
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LETTERS Lack of Evolutionary Conservation at Positions Important for Thermal Stability in the Yeast ODCase Protein
Mutations destabilizing the spatial structure of proteins can persist in populations if they are fixed by drift or compensated by other mutations. The prevalence and dynamics of these processes remain largely unrecognized. A suitable target to screen for both deleterious and compensatory mutations is the URA3 gene in yeast. We identified 13 positions in which a single missense substitution caus...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2009
ISSN: 1537-1719,0737-4038
DOI: 10.1093/molbev/msp066